Revolt is right.
Logitechs deamon loads at startup, and wants to be the last startup item. So You can't use USB overdrive, because it's overriden by Logitechs Daemon.
I like the Logitechs daemon. -Just not in GhR.
I combine killing the Daemon, (lol,) and renicing GhR, using an app. called 'Process Wizard'. (Look at VersionTracker.com.) Renicing GhR can be a bit tricky, but it's usefull. -Gives me a few extra FPS, which is really nice, considering that I'm on a 400MHz, 32 MB GFX, G4. (The first of the G4s, with a Radeon 7000 GFX card.)
To kill a the Logitech daemon with 'Process Wizard', Click the menubar icon, click where it says 'Applications', select 'Background Apps', right/control-click 'Logitech Control Center Daemon', and select 'Kill'. This removes the daemon, frees up a little mem, and there by lets You map ALL 8 buttons and the wheel, (if You're using a Logitech MX500,) on OS X. -Without using USB Overdrive.
Only 2 small anoying things about this approach.
1. You HAVE to remember to kill the daemon (eeeeevery time) when You wanna play GhR.
2. You want the driver back when back from playing GhR. -At least I do. But that doesn't mean You have to reboot.
Just double-click the daemon. Here is it's location:
/Library/Application Support/Logitech/LCCDaemon
It has a deacent icon, so it doesn't look like crap, if You place it in your Dock(.app), Dragthing, or similar.
Just my 2 ?
Peace and bliss, friends,
??VieiA..
(No wait!! DIE IN AGONY, AWFUL SCUMM!!)